NEW ORLEANS (AP) — Percy Sledge, who soared from part-time singer and hospital orderly to lasting fame with his aching, forlorn performance on the classic "When a Man Loves a Woman," died Tuesday in Louisiana. He was 74.

Dr. William "Beau" Clark, coroner for East Baton Rouge Parish, confirmed to The Associated Press that Sledge died early Tuesday morning, about an hour after midnight, of natural causes in hospice care.

A No. 1 hit in 1966, "When a Man Loves a Woman" was Sledge's debut single, an almost unbearably heartfelt ballad with a resonance he never approached again. Few singers could have. Its mood set by a mournful organ and dirge-like tempo, "When a Man Loves a Woman" was for many the definitive soul ballad, a testament of blinding, all-consuming love haunted by fear and graced by overwhelming emotion.

"When a Man Loves a Woman" was a personal triumph for Sledge, who seemed on the verge of sobbing throughout the production, and a breakthrough for Southern soul. It was the first No. 1 hit from Alabama's burgeoning Muscle Shoals music scene, where Aretha Franklin and the Rolling Stones among others would record, and the first gold record for Atlantic Records.

Atlantic Records executive Jerry Wexler later called the song "a transcendent moment" and "a holy love hymn." Sledge's hit became a standard that sustained his long touring career in the U.S., Europe and South Africa, when he averaged 100 performances a year, and led to his induction into the Rock and Roll Hall of Fame in 2005. It was a favorite at weddings — Sledge himself did the honors at a ceremony for musician and actor Steve Van Zandt — and often turned up in movies, including "The Big Chill," ''The Crying Game" and a 1994 Meg Ryan drama named for the song's title.

"When a Man Loves a Woman" was re-released after being featured in Oliver Stone's Vietnam War film "Platoon" in 1987 and reached No. 2 in Britain. Michael Bolton topped the charts in the 1990s with a cover version and Rolling Stone magazine later ranked it No. 53 on its list of the greatest songs of all time.

Recognizable by his wide, gap-toothed smile, Sledge had a handful of other hits between 1966 and 1968, including "Warm and Tender Love," ''It Tears Me Up," ''Out of Left Field" and "Take Time to Know Her." He returned to the charts in 1974 with "I'll Be Your Everything."

Before he became famous, Sledge worked in the cotton fields around his hometown of Leighton in northwest Alabama and took a job in a hospital in nearby Sheffield. He also spent weekends playing with a rhythm-and-blues band called the Esquires. A patient at the hospital heard him singing while working and recommended him to record producer Quin Ivy.

In the 2013 documentary "Muscle Shoals," Sledge recalled recording the song: "When I came into the studio, I was shaking like a leaf. I was scared." He added that it was the "same melody that I sang when I was out in the fields. I just wailed out in the woods and let the echo come back to me."

The composition of the song has long been a mystery. Some thought that Sledge wrote it himself. Sledge said he was inspired by a girlfriend who left him for a modeling career after he was laid off from a construction job in 1965, but he gave the songwriting credits to two Esquires bandmates, bassist Calvin Lewis and organist Andrew Wright, who helped him with the song.

While identified with the Muscle Shoals music scene, Sledge spent most of his career living in Baton Rouge. He was inducted in the Alabama Music Hall of Fame in 1993 and the Louisiana Music Hall of Fame in 2007.

In April 1994, Sledge pleaded guilty in federal court to tax evasion involving income from concerts in the late 1980s. He was sentenced to six months in a halfway house, given five years of probation, and ordered to pay $96,000 in back taxes and fines. When he pleaded guilty, he told the judge, "I knew I owed more."

Sledge had surgery for liver cancer in January 2014 but soon resumed touring.